Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a paradigm for interbacterial competition among pathogens of the human respiratory tract.

نویسندگان

  • Elizabeth A Shakhnovich
  • Samantha J King
  • Jeffrey N Weiser
چکیده

Both Neisseria meningitidis and Haemophilus influenzae are capable of mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate the cell surfaces of both these species, which reside in and possibly compete for the same host niche.

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عنوان ژورنال:
  • Infection and immunity

دوره 70 12  شماره 

صفحات  -

تاریخ انتشار 2002